2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-107582
    JW480
    		Inhibitor 99.54%
    JW480 is a potent and selective inhibitor of a serine hydrolase enzyme KIAA1363.
    JW480
  • HY-108904
    Urokinase, Human urine
    Urokinase (peptidolytic) (EC 3.4.21.73) is a serine protease, an inactive form (zymogen) of the serine protease plasminogen. Activation of plasmin triggers a proteolytic cascade reaction, which in turn participates in thrombolysis or extracellular matrix degradation, implicated in vascular disease and cancer-related research.
    Urokinase, Human urine
  • HY-162266
    C3TD879
    		99.42%
    C3TD879 is an inhibitor of citron kinase (CITK), an AGC family serine/threonine kinase that regulates cytokinesis. C3TD879 inhibits CITK catalytic activity with an IC50 of 12 nM. C3TD879 does not induce CITK knockdown effects on cell proliferation, cell cycle progression, or cytokinesis, but rather reduces the activity by directly binding full-length human CITK (NanoBRET Kd< 10 nM).
    C3TD879
  • HY-P5018
    NOTA-AE105
    		Ligand 98.91%
    NOTA-AE105 is an PET ligand of urokinase-type plasminogen activator receptor (uPAR), which can be radiolabeled by 64Cu and 68Ga. 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation. NOTA-AE105 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    NOTA-AE105
  • HY-118969
    BMS-262084
    		Inhibitor 98.06%
    BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects.
    BMS-262084
  • HY-127034
    Antipain dihydrochloride
    		Inhibitor
    Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.
    Antipain dihydrochloride
  • HY-P5376
    MeO-Suc-Arg-Pro-Tyr-pNA
    		Substrate 98.50%
    MeOSuc-Arg-Pro-Tyr-pNA (S-2586) is a biological active peptide. (chymotrypsin substrate)
    MeO-Suc-Arg-Pro-Tyr-pNA
  • HY-137814
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
    		99.38%
    4-Nitrophenyl 4-guanidinobenzoate (NPGB) hydrochloride is a potent sperm acrosin inhibitor, and also a trypsin substrate.
    4-Nitrophenyl 4-guanidinobenzoate hydrochloride
  • HY-124762
    TNIK-IN-1
    		Inhibitor 98.86%
    TNIK-IN-1 (Compound 1) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 65 nM, that has antitumor activity.
    TNIK-IN-1
  • HY-W087937
    Benzamidine hydrochloride hydrate
    		Inhibitor 99.96%
    Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively.
    Benzamidine hydrochloride hydrate
  • HY-101270
    STK16-IN-1
    		Inhibitor 99.95%
    STK16-IN-1 is a STK16 kinase inhibitor with an IC50 of 295 nM.
    STK16-IN-1
  • HY-P2810
    Rennin
    Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production.
    Rennin
  • HY-19303B
    CRA-2059 TFA
    		Inhibitor 99.62%
    CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ).
    CRA-2059 TFA
  • HY-114080
    Patamostat
    		Inhibitor 98.13%
    Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. Patamostat may possess suppressing effects on pathogenesis and development of acute pancreatitis.
    Patamostat
  • HY-107759
    Butabindide oxalate
    		Inhibitor 98.98%
    Butabindide (UCL-1397) oxalate is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation.
    Butabindide oxalate
  • HY-114330A
    ZK824859 hydrochloride
    		Inhibitor 99.03%
    ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively.
    ZK824859 hydrochloride
  • HY-E70227
    Cathepsin G, human neutrophils
    Cathepsin G, human neutrophils (CTSH; ACC4) a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation.
    Cathepsin G, human neutrophils
  • HY-108910B
    TLCK-treated Chymotrypsin
    TLCK-treated Chymotrypsin is a serine protease. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids. TLCK treated to inactivate residual tryspin activity.
    TLCK-treated Chymotrypsin
  • HY-33900
    Dihydrofuran-3(2H)-one
    		Inhibitor 99.99%
    Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) can be used to synthesize cyclic ketone inhibitors that inhibit the serine protease plasmin and increase its inhibitory activity.
    Dihydrofuran-3(2H)-one
  • HY-19727A
    FOY 251
    		Inhibitor 98.86%
    FOY 251, an anti-proteolytic active metabolite Camostate (HY-13512), acts as a proteinase inhibitor. FOY 251 inhibits SARS-CoV-2 infection in cells assay.
    FOY 251
Cat. No. Product Name / Synonyms Application Reactivity